What is HLA? How is HLA determined and inherited? How is this used to match a donor and recipient for a tissue transplantation?

Please read the case study, Giving Birth to Someone Else’s Children? A Case of Disputed Maternity, and then answer the following questions: From Part I, Karen needs a kidney transplant and her sons are being tested for possible donors. However, it seems that the blood test have indicated that neither of her sons are her children based on HLA matching. 1. What is HLA? How is HLA determined and inherited? How is this used to match a donor and recipient for a tissue transplantation? 2. What are some possible explanations for Karen’s situation? How would you test these hypotheses?

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